Impact of Omega-3 and Omega-9 fatty acids enriched total parenteral nutrition on blood chemistry and inflammatory markers in septic patients

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dc.contributor.authorGultekin, Gamze
dc.contributor.authorŞahin, Habibe
dc.contributor.authorİnanç, Neriman
dc.contributor.authorUyanik, Fatma
dc.contributor.authorOk, Engin
dc.date.accessioned2025-02-24T17:18:56Z
dc.date.available2025-02-24T17:18:56Z
dc.date.issued2014
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractObjective: Lipid emulsions containing omega-3 are known to have positive effects on patient's prognosis due to anti-inflammatory properties. The aim of this study was to investigate the effects of omega-3 enriched total parenteral nutrition (TPN) emulsion containing omega-9 on biochemical parameters, inflammatory mediators in septic patients. Methods: Thirty-two participants who were not fed orally for over five days and needing TPN support were included in this prospective, randomized and double-blind clinical study. Patients were randomly divided into control (n=16), treatment (n=16) groups. The treatment group received TPN containing 80% olive oit+20% soy oil additionally 10 g fish oil enriched TPN. Control group received only olive oil containing standard lipid emulsion (1.3 +/- 0.1 g/kg/day).. Blood samples were collected for biochemical analysis on the 1st and 6th days of study. Results: The serum albumin levels significantly increased (p < 0.05) in both groups whereas total protein and prealbumin levels did not show any significant changes. In treatment group, significant decreases were determined in LTB4 and CRP levels (p < 0.05) while decreases in IL-6, TNF-alpha and leukocyte levels were not significant. No statistically significant changes were found in LTB4, CRP, IL-6, TNF-alpha and leukocyte levels of controls. Conclusion: Results of the study have shown that omega-3 enriched TPN solution containing omega-9 contributes to decrease in the levels of inflammatory mediators and to improvement in the biochemical parameters in septic patients.
dc.identifier.endpage304
dc.identifier.issn1682-024X
dc.identifier.issue2
dc.identifier.pmid24772131
dc.identifier.scopus2-s2.0-84894629655
dc.identifier.scopusqualityQ1
dc.identifier.startpage299
dc.identifier.urihttps://hdl.handle.net/20.500.14440/924
dc.identifier.volume30
dc.identifier.wosWOS:000334562700015
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherProfessional Medical Publications
dc.relation.ispartofPakistan Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250201
dc.subjectBiochemical parameters
dc.subjectInflammatory markers
dc.subjectOlive oil
dc.subjectSepsis
dc.subjectTPN
dc.titleImpact of Omega-3 and Omega-9 fatty acids enriched total parenteral nutrition on blood chemistry and inflammatory markers in septic patients
dc.typeArticle

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