Impact of Omega-3 and Omega-9 fatty acids enriched total parenteral nutrition on blood chemistry and inflammatory markers in septic patients

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Tarih

2014

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Professional Medical Publications

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Objective: Lipid emulsions containing omega-3 are known to have positive effects on patient's prognosis due to anti-inflammatory properties. The aim of this study was to investigate the effects of omega-3 enriched total parenteral nutrition (TPN) emulsion containing omega-9 on biochemical parameters, inflammatory mediators in septic patients. Methods: Thirty-two participants who were not fed orally for over five days and needing TPN support were included in this prospective, randomized and double-blind clinical study. Patients were randomly divided into control (n=16), treatment (n=16) groups. The treatment group received TPN containing 80% olive oit+20% soy oil additionally 10 g fish oil enriched TPN. Control group received only olive oil containing standard lipid emulsion (1.3 +/- 0.1 g/kg/day).. Blood samples were collected for biochemical analysis on the 1st and 6th days of study. Results: The serum albumin levels significantly increased (p < 0.05) in both groups whereas total protein and prealbumin levels did not show any significant changes. In treatment group, significant decreases were determined in LTB4 and CRP levels (p < 0.05) while decreases in IL-6, TNF-alpha and leukocyte levels were not significant. No statistically significant changes were found in LTB4, CRP, IL-6, TNF-alpha and leukocyte levels of controls. Conclusion: Results of the study have shown that omega-3 enriched TPN solution containing omega-9 contributes to decrease in the levels of inflammatory mediators and to improvement in the biochemical parameters in septic patients.

Açıklama

Anahtar Kelimeler

Biochemical parameters, Inflammatory markers, Olive oil, Sepsis, TPN

Kaynak

Pakistan Journal of Medical Sciences

WoS Q Değeri

Q2

Scopus Q Değeri

Q1

Cilt

30

Sayı

2

Künye