The protective effect of Myrtus communis L. against experimental kidney stone in rats

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dc.authoridomerli, ayse/0000-0003-3693-6997
dc.authoridSeker Karatoprak, Gokce/0000-0001-5829-6914
dc.authoridYILMAZ, Halil/0000-0002-8234-4901
dc.authoridATES, Sukru/0000-0001-7096-2481
dc.authoridNisari, Mehtap/0000-0002-1126-7478
dc.authoridTastan, Mustafa/0000-0002-1465-3681
dc.contributor.authorYllmaz, Halil
dc.contributor.authorEkinci, Nihat
dc.contributor.authorOmerli, Ayse
dc.contributor.authorNisari, Mehtap
dc.contributor.authorYay, Arzu Hanim
dc.contributor.authorUlger, Harun
dc.contributor.authorKaratoprak, Gokce Seker
dc.date.accessioned2025-02-24T17:18:33Z
dc.date.available2025-02-24T17:18:33Z
dc.date.issued2023
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Fizyoterapi ve Rehabilitasyon Bölümü
dc.description.abstractThe aim of this study is to investigate the protective effect of 70% methanolic extract of Myrtus communis L. leaves (300 mg/kg) against the kidney stone modeling created by (0.75%) ethylene glycole. Twenty-eight, 10 week's Sprague Dawley male rats were divided into four groups (n=7) as the control group, ethylene glycol (EG) group, M. communis (MC) group and protective (EG +MC) group. For 28 days, while 0.75% EG was given by adding it to drinking water to occur kidney stone model, MC was given by gavage to test the protective effect. 24 h' urine samples were taken, and calcium, creatinine, uric acid, magnesium, citrate and oxalate were evaluated. On the 28th day, the rats were sacrificed, and their kidneys were removed. Kidney tissues were examined with hematoxylin eosin (HE) staining and kidney stones formed with Pizzolato's (PZ) staining technique were shown. M. communis extract brought abnormal urine parameter values closer to the control group. Additionally, it was concluded that the tissue degeneration and number of stones decreased in the protective group. M. communis extract has a protective effect against the kidney stone modeling which created by EG.
dc.description.sponsorshipErciyes University Scientific Research Projects Coordination Unit [TDK-2018-8431]
dc.description.sponsorshipThis study was produced from Halil Yilmaz's PhD thesis The effect of Myrtus Communis L. on Experimental Kidney Stone in Rats. Financial source of this investigation was funded by Erciyes University Scientific Research Projects Coordination Unit (TDK-2018-8431).
dc.identifier.doi10.1007/s13596-021-00620-4
dc.identifier.endpage249
dc.identifier.issn2662-4052
dc.identifier.issn2662-4060
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85122290546
dc.identifier.scopusqualityQ2
dc.identifier.startpage241
dc.identifier.urihttps://doi.org/10.1007/s13596-021-00620-4
dc.identifier.urihttps://hdl.handle.net/20.500.14440/745
dc.identifier.volume23
dc.identifier.wosWOS:000738422500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofAdvances in Traditional Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250201
dc.subjectM. communis
dc.subjectCalcium oxalate
dc.subjectEthylene glicole
dc.subjectPizzolato's
dc.subjectStaining
dc.subjectUrine
dc.titleThe protective effect of Myrtus communis L. against experimental kidney stone in rats
dc.typeArticle

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