The protective effect of Myrtus communis L. against experimental kidney stone in rats

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Tarih

2023

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Springer

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

The aim of this study is to investigate the protective effect of 70% methanolic extract of Myrtus communis L. leaves (300 mg/kg) against the kidney stone modeling created by (0.75%) ethylene glycole. Twenty-eight, 10 week's Sprague Dawley male rats were divided into four groups (n=7) as the control group, ethylene glycol (EG) group, M. communis (MC) group and protective (EG +MC) group. For 28 days, while 0.75% EG was given by adding it to drinking water to occur kidney stone model, MC was given by gavage to test the protective effect. 24 h' urine samples were taken, and calcium, creatinine, uric acid, magnesium, citrate and oxalate were evaluated. On the 28th day, the rats were sacrificed, and their kidneys were removed. Kidney tissues were examined with hematoxylin eosin (HE) staining and kidney stones formed with Pizzolato's (PZ) staining technique were shown. M. communis extract brought abnormal urine parameter values closer to the control group. Additionally, it was concluded that the tissue degeneration and number of stones decreased in the protective group. M. communis extract has a protective effect against the kidney stone modeling which created by EG.

Açıklama

Anahtar Kelimeler

M. communis, Calcium oxalate, Ethylene glicole, Pizzolato's, Staining, Urine

Kaynak

Advances in Traditional Medicine

WoS Q Değeri

N/A

Scopus Q Değeri

Q2

Cilt

23

Sayı

1

Künye