Does capsaicin have therapeutic benefits in human colon adenocarcinoma? Selection of the most reliable dose via AgNOR

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dc.contributor.authorNisari, Mustafa
dc.contributor.authorEroz, Recep
dc.date.accessioned2025-02-24T17:19:10Z
dc.date.available2025-02-24T17:19:10Z
dc.date.issued2020
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractBackground/aim: To determine the effect of different doses of capsaicin on AgNOR protein synthesis in human colon adenocarcinoma derivate from colon cancer (Cato-2 cell). Materials and methods: In this experimental study, after the cultured of Caco-2 cell line, the cells are divided into 4 groups as control and different capsaicin exposed doses (25u mu, 50u mu, and 75u mu). Mean AgNOR number and total AgNOR area/nuclear area (TAA/NA) were calculated. Results: A significant differences were detected between control and capsaicin (50u mu) (P = 0.001), between control and capsaicin (75u mu) (P = 0.000), between capsaicin (25u mu) and capsaicin (50u mu) (P = 0.001) and between capsaicin (25u mu) and capsaicin (75u mu) (P = 0.000) for TAA/NA. Also, there were significant differences between control and capsaicin (50u mu) (P = 0.001), between control and capsaicin (75u mu) (P = 0.000), between capsaicin (25u mu) and capsaicin (50u mu) (P = 0.000) and between capsaicin (25u mu) and capsaicin (75u mu) (P = 0.000) for mean AgNOR number. Conclusion: A certain amount of capsaicin has a protective effect against colon adenocarcinoma and the dose concentrations are important for the most reliable treatment.
dc.identifier.doi10.3906/sag-2003-251
dc.identifier.endpage1081
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4
dc.identifier.pmid32490651
dc.identifier.scopus2-s2.0-85090725320
dc.identifier.scopusqualityQ1
dc.identifier.startpage1076
dc.identifier.trdizinid354743
dc.identifier.urihttps://doi.org/10.3906/sag-2003-251
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/354743
dc.identifier.urihttps://hdl.handle.net/20.500.14440/1037
dc.identifier.volume50
dc.identifier.wosWOS:000613005100056
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250201
dc.subjectAgNOR
dc.subjectcapsaicin
dc.subjecthuman colon adenocarcinoma
dc.subjectrDNA
dc.subjectcaco-2 cell line
dc.titleDoes capsaicin have therapeutic benefits in human colon adenocarcinoma? Selection of the most reliable dose via AgNOR
dc.typeArticle

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