Does capsaicin have therapeutic benefits in human colon adenocarcinoma? Selection of the most reliable dose via AgNOR
Yükleniyor...
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Tubitak Scientific & Technological Research Council Turkey
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background/aim: To determine the effect of different doses of capsaicin on AgNOR protein synthesis in human colon adenocarcinoma derivate from colon cancer (Cato-2 cell). Materials and methods: In this experimental study, after the cultured of Caco-2 cell line, the cells are divided into 4 groups as control and different capsaicin exposed doses (25u mu, 50u mu, and 75u mu). Mean AgNOR number and total AgNOR area/nuclear area (TAA/NA) were calculated. Results: A significant differences were detected between control and capsaicin (50u mu) (P = 0.001), between control and capsaicin (75u mu) (P = 0.000), between capsaicin (25u mu) and capsaicin (50u mu) (P = 0.001) and between capsaicin (25u mu) and capsaicin (75u mu) (P = 0.000) for TAA/NA. Also, there were significant differences between control and capsaicin (50u mu) (P = 0.001), between control and capsaicin (75u mu) (P = 0.000), between capsaicin (25u mu) and capsaicin (50u mu) (P = 0.000) and between capsaicin (25u mu) and capsaicin (75u mu) (P = 0.000) for mean AgNOR number. Conclusion: A certain amount of capsaicin has a protective effect against colon adenocarcinoma and the dose concentrations are important for the most reliable treatment.
Açıklama
Anahtar Kelimeler
AgNOR, capsaicin, human colon adenocarcinoma, rDNA, caco-2 cell line
Kaynak
Turkish Journal of Medical Sciences
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
50
Sayı
4
