Total aflatoxin and ochratoxin A levels, dietary exposure and cancer risk assessment in dried fruits in Türkiye

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dc.authoridDishan, Adalet/0000-0001-8097-1648
dc.contributor.authorSahin, Gizem Aytekin
dc.contributor.authorAykemat, Yusuf
dc.contributor.authorYildiz, Aysegul Tugba
dc.contributor.authorDishan, Adalet
dc.contributor.authorİnanç, Neriman
dc.contributor.authorGonulalan, Zafer
dc.date.accessioned2025-02-24T17:18:53Z
dc.date.available2025-02-24T17:18:53Z
dc.date.issued2024
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractThis study aimed to measure total aflatoxin (AF) (AFB1, AFB2, AFG1, and AFG2) and ochratoxin A (OTA) levels in dried fruit samples and to evaluate the potential dietary exposure and cancer risk to these mycotoxins in Kayseri/Turkiye. Dried fruit samples were collected between April-May 2021. A total of 11 dried grapes and apricot samples, 7 dried fig and plum samples were collected. Total aflatoxins and OTA in dried fruits were determined by ELISA method. Then, the margin of exposure (MOE) and cancer risk were calculated. Total AF was detected in dried fruit samples between 42.86%, and 100%. Between 18.18% and 57.14% of samples exceeded the European Commission (EC) limits for total AF. Moreover, OTA was detected in all samples. Between 71.43% and 100% of samples exceeded the EC limits for OTA. Cancer risk due to OTA exposure was higher than total AF and it was determined that OTA exposure could pose a risk for public health (MOE < 10,000). Although mycotoxin exposure seems to be low due to the low consumption of dried fruit in Turkiye, the risk of exposure and cancer may increase because of complying with the recommendations of the dietary guidelines. The findings provide new insights into exposure to total AF and OTA through the consumption of dried fruit.
dc.description.sponsorshipNuh Naci Yazgan University Scientific Research Fund [NNY-BAP] [2019-SA-BP-4]
dc.description.sponsorshipThis work was supported by the Nuh Naci Yazgan University Scientific Research Fund [NNY-BAP] [2019-SA-BP-4].
dc.identifier.doi10.1016/j.toxicon.2023.107540
dc.identifier.issn0041-0101
dc.identifier.issn1879-3150
dc.identifier.pmid38042309
dc.identifier.scopus2-s2.0-85178566771
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.toxicon.2023.107540
dc.identifier.urihttps://hdl.handle.net/20.500.14440/881
dc.identifier.volume237
dc.identifier.wosWOS:001132478600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofToxicon
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250201
dc.subjectAflatoxins
dc.subjectDietary risk assessment
dc.subjectDietary exposure
dc.subjectDried fruits
dc.subjectOchratoxin A
dc.titleTotal aflatoxin and ochratoxin A levels, dietary exposure and cancer risk assessment in dried fruits in Türkiye
dc.typeArticle

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