The effect of different treatment protocols with diode laser on regeneration in axonetmesis injuries of the inferior alveolar nerve: an animal study

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dc.authoridOnder, Gozde Ozge/0000-0002-0515-9286
dc.authoridGURGAN, CEM/0000-0003-0811-008X
dc.authoridYay, Arzu Hanim/0000-0002-0541-8372
dc.contributor.authorOztuerk, Kubra
dc.contributor.authorKuzu, Turan Emre
dc.contributor.authorGurgan, Cem A.
dc.contributor.authorOnder, Goezde oezge
dc.contributor.authorYay, Arzu
dc.date.accessioned2025-02-24T17:18:55Z
dc.date.available2025-02-24T17:18:55Z
dc.date.issued2023
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.description.abstractThe inferior alveolar nerve can be damaged during dental procedures, leading to symptoms, such as tingling, numbness, and reduced quality of life. Recovery depends on factors such as medications, surgery, and photobiomodulation therapy. Photobiomodulation therapy has shown the potential to improve nerve function and reduce regeneration time; however, there is no standard treatment protocol yet. This study aimed to examine the effect of diode lasers on nerve regeneration in patients with axonetmesis injuries. In this experiment on animals, Wistar rats' damaged sensory systems were treated with lasers to restore them. Animals were randomly divided into six groups: a sham group, a control group, and four laser treatment groups(1st group: performed every day, 10 sessions; 2nd group: performed every 2 days, 10 sessions; 3rd group: performed every day, 20 sessions; and 4th group: performed every 2 days, 20 sessions). Sensory function was determined using the Semmes-Weinstein monofilament test, which was repeated after the surgical procedure. The results showed that the 20-session group had the best improvement, most closely resembling the group without sensory test damage. The histomorphometric results showed that the number of axons was significantly lower in the group that received 10 daily sessions and in the control group than in the undamaged nerve. Axon diameter was lower in all groups than in the sham group. In conclusion, the remarkable aspect of this study is that consecutive-day 20-session laser treatment showed better improvement than the over-the-day 20-session treatment protocol.
dc.description.sponsorshipNuh Naci Yazgan University Scientific Research Project Coordination Unit [2020-SA.DH-BP/15]
dc.description.sponsorshipThis study was supported by the Nuh Naci Yazgan University Scientific Research Project Coordination Unit(2020-SA.DH-BP/15).
dc.identifier.doi10.1007/s10103-023-03834-x
dc.identifier.issn0268-8921
dc.identifier.issn1435-604X
dc.identifier.issue1
dc.identifier.pmid37515606
dc.identifier.scopus2-s2.0-85165996271
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s10103-023-03834-x
dc.identifier.urihttps://hdl.handle.net/20.500.14440/912
dc.identifier.volume38
dc.identifier.wosWOS:001039114600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer London Ltd
dc.relation.ispartofLasers in Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250201
dc.subjectAxonotmesis
dc.subjectInferior alveolar nerve
dc.subjectPhotobiomodulation
dc.subjectLow-level laser theraphy
dc.titleThe effect of different treatment protocols with diode laser on regeneration in axonetmesis injuries of the inferior alveolar nerve: an animal study
dc.typeArticle

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