Release of mercury from amalgam filling and its relationship with metallothionein and superoxide dismutase

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dc.contributor.authorGul, Pinar
dc.contributor.authorKarataş, Özcan
dc.contributor.authorSagsoz, Omer
dc.contributor.authorAskin, Seda
dc.contributor.authorTurkeri, Ozge
dc.contributor.authorKiziltunc, Ahmet
dc.date.accessioned2025-02-24T17:18:28Z
dc.date.available2025-02-24T17:18:28Z
dc.date.issued2023
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractPurpose This study aims at determining the amount of mercury released over time from amalgam after treatment in healthy subjects and to examine the relation of mercury with serum MT-1 and SOD-1 levels.Materials and Methods Amalgam filling was applied to the 15 subjects aged 19-22 years and blood samples were collected before treatment and 1 day, 7 days, 21 days and 35 days after treatment. Mercury analysis of serum samples was performed using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). In addition, MT-1 and SOD-1 levels in serum samples were measured using commercial enzyme-linked immunosorbent assay (ELISA). Friedman test and Spearman's correlation analysis was performed to analyse the data. p value was interpreted in significance level of 0.05.Results As a result of the analysis for MT-1, it was found that the values decreased over time and this decrease was statistically significant after 21 days (p<0.05). In addition, it was found that SOD-1 decreased over time, but this decrease was not statistically significant . In terms of released mercury, there was no statistically significant difference among the values of mercury released over time . According to the results of correlation analysis, no statistically significant relationship was found among the variables.Conclusion The results of the present study indicated that the amount of mercury released from the tested amalgam were found to be tolerable and no significant relationship was found between MT-1 and SOD-1.
dc.identifier.doi10.26650/eor.20231086355
dc.identifier.endpage21
dc.identifier.issn2630-6158
dc.identifier.issn2651-2823
dc.identifier.issue1
dc.identifier.pmid37020637
dc.identifier.scopus2-s2.0-85168108689
dc.identifier.scopusqualityQ3
dc.identifier.startpage16
dc.identifier.trdizinid1166831
dc.identifier.urihttps://doi.org/10.26650/eor.20231086355
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1166831
dc.identifier.urihttps://hdl.handle.net/20.500.14440/674
dc.identifier.volume57
dc.identifier.wosWOS:000931699600003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherIstanbul Univ Press, Istanbul Univ Rectorate
dc.relation.ispartofEuropean Oral Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250201
dc.subjectAmalgam
dc.subjectantioxidants
dc.subjectmercury
dc.subjectmetallothionein
dc.subjectsuperoxide dismutase
dc.titleRelease of mercury from amalgam filling and its relationship with metallothionein and superoxide dismutase
dc.typeArticle

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