Anti-inflammatory and pro-regenerative effects of a monoterpene glycoside on experimental periodontitis in a rat model of diabetes

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dc.authoridGURGAN, CEM/0000-0003-0811-008X
dc.contributor.authorKuzu, Turan Emre
dc.contributor.authorOzturk, Kuebra
dc.contributor.authorGurgan, Cem A.
dc.contributor.authorYay, Arzu
dc.contributor.authorGoktepe, Ozge
dc.contributor.authorKantarci, Alpdogan
dc.date.accessioned2025-02-24T17:18:40Z
dc.date.available2025-02-24T17:18:40Z
dc.date.issued2023
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.description.abstractObjectivePaeoniflorin (Pae) is a monoterpene glycoside with immune-regulatory effects. Several studies have already demonstrated the impact of Pae on periodontitis, but its effect on diabetic periodontitis is unclear. In this study, our aim was to test the hypothesis that Pae had a strong anti-inflammatory effect that prevented bone loss in diabetic periodontitis. MethodsThirty male Wistar albino rats were randomly divided into control (healthy, n = 10), periodontitis (PD) + diabetes (DM; n = 10), and PD + DM + Pae (n = 10) groups. Ligature-induced periodontitis was created by placing 4-0 silk ligatures around the lower first molars on both sides of the mandibulae. Experimental DM was created via an injection of 50 mg/kg and streptozotocin (STZ). Hyperglycemia was confirmed by the blood glucose levels of rats (>300 mg/dL). The bone mineral density (BMD), trabecular number, trabecular thickness, and bone loss were measured by micro-CT. The expression levels of IL-1 & beta;, IL-6, and TNF-& alpha; were measured in tissue homogenates by ELISA. ResultsThe PD + DM + Pae group had significantly less alveolar crest resorption when compared to the PD + DM group. There was also a significant difference between the PD + DM + Pae group compared to PD + DM group in trabecular thickness, BMD, and the number of trabeculae. Pae application led to a statistically significant decrease in IL-1 & beta;, IL-6, and TNF-& alpha; levels in diabetic periodontitis. ConclusionSystemic application of Pae suppressed inflammation caused by PD and DM, leading to reduced bone loss and enhanced bone quality.
dc.description.sponsorshipNuh Naci Yazgan University Scientific Research Projects Coordination Unit [2020-SA.D H . B P - 14]
dc.description.sponsorshipThis study was supported by the Nuh Naci Yazgan University Scientific Research Projects Coordination Unit(2020-SA.D H . B P - 14 ) .
dc.identifier.doi10.1111/jre.13151
dc.identifier.endpage938
dc.identifier.issn0022-3484
dc.identifier.issn1600-0765
dc.identifier.issue5
dc.identifier.pmid37340760
dc.identifier.scopus2-s2.0-85162701573
dc.identifier.scopusqualityQ1
dc.identifier.startpage932
dc.identifier.urihttps://doi.org/10.1111/jre.13151
dc.identifier.urihttps://hdl.handle.net/20.500.14440/783
dc.identifier.volume58
dc.identifier.wosWOS:001011717600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Periodontal Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250201
dc.subjectalveolar bone
dc.subjectinflammation
dc.subjectperiodontitis
dc.titleAnti-inflammatory and pro-regenerative effects of a monoterpene glycoside on experimental periodontitis in a rat model of diabetes
dc.typeArticle

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