Effects of mesenchymal stem cell transfer on orthodontically induced root resorption and orthodontic tooth movement during orthodontic arch expansion protocols: an experimental study in rats

Basit Öğe Kaydı
dc.authoridAcar, Mustafa Burak/0000-0002-9109-6575
dc.authoridKARA, Ayca/0000-0003-2586-4756
dc.authoridOZCAN, SERVET/0000-0002-9914-8843
dc.authoridAMUK, MEHMET/0000-0001-6390-7169
dc.contributor.authorAmuk, Nisa Gul
dc.contributor.authorKurt, Gokmen
dc.contributor.authorKarsli, Erol
dc.contributor.authorOzcan, Servet
dc.contributor.authorAcar, Mustafa Burak
dc.contributor.authorAmuk, Mehmet
dc.contributor.authorLekesizcan, Ayca
dc.date.accessioned2025-02-24T17:18:41Z
dc.date.available2025-02-24T17:18:41Z
dc.date.issued2020
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.description.abstractObjectives: The aim was to evaluate the effects of mesenchymal stem cell (MSC) transfer to periodontal ligament (PDL) on the inhibition and/or repair of orthodontically induced root resorption (OIRR) during and after arch expansion and on the orthodontic tooth movement (OTM) rate of the maxillary first molar teeth of rats. Material and methods: Sixty Wistar rats were divided into three groups as the untreated group, MSC and control injections during the expansion period group (EMSC-EC), and MSC and control injections at the retention period group (RMSC-RC). Fifty grams of orthodontic force was applied to the maxillary first molar teeth of the rats for 14 days in the vestibular direction, and then, 20 days of retention was carried out. MSCs and control injections were performed every 3 days in the EC, RC, EMSC, and RMSC groups. At the end of the experiment, samples were prepared for OTM evaluation, mRNA expression analysis, micro-computed tomography measurements, cementum thickness calculations, and structural examinations. Results: The amount of OTM in EMSC group was significantly higher than in EC group (P < 0.001). MSC transfer during the expansion and retention periods reduced the number of resorption lacunae, volumetric and linear resorptive measurements, and cyclooxygenase-2 and receptor activator of nuclear factor kappa B ligand (RANKL) mRNA expression levels, and increased the osteoprotegerin (OPG) expression levels, OPG/RANKL ratio, and cementum thickness in the EMSC and RMSC groups. Conclusions: MSC transfer to PDL during expansion increased the amount of OTM. Injection of MSC during the retention period was found to be slightly more effective in prevention and/or repair of OIRR than MSC transfer during the expansion period.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [116S400]
dc.description.sponsorshipThe Scientific and Technological Research Council of Turkey (TUBITAK) with the project number 116S400.
dc.identifier.doi10.1093/ejo/cjz035
dc.identifier.endpage316
dc.identifier.issn0141-5387
dc.identifier.issn1460-2210
dc.identifier.issue3
dc.identifier.pmid31143928
dc.identifier.scopus2-s2.0-85090633355
dc.identifier.scopusqualityQ1
dc.identifier.startpage305
dc.identifier.urihttps://doi.org/10.1093/ejo/cjz035
dc.identifier.urihttps://hdl.handle.net/20.500.14440/794
dc.identifier.volume42
dc.identifier.wosWOS:000607046300011
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Press
dc.relation.ispartofEuropean Journal of Orthodontics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250201
dc.subjectRapid Maxillary Expansion
dc.subjectAlveolar Bone
dc.subjectBorne Expanders
dc.subjectTissue-Borne
dc.subjectDifferentiation
dc.subjectInterleukin-11
dc.subjectRegeneration
dc.subjectExpression
dc.subjectDuration
dc.subjectForce
dc.titleEffects of mesenchymal stem cell transfer on orthodontically induced root resorption and orthodontic tooth movement during orthodontic arch expansion protocols: an experimental study in rats
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Diş Hekimliği Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu