The protective role of melatonin and curcumin in the testis of young and aged rats

Basit Öğe Kaydı
dc.authoridBAKAL MURATOGLU, Saide/0000-0002-6861-9171
dc.authoridKeskin-Aktan, Arzu/0000-0002-2878-0841
dc.contributor.authorMuratoglu, Saide
dc.contributor.authorDizakar, Ozen S. Akarca
dc.contributor.authorAktan, Arzu Keskin
dc.contributor.authorOmeroglu, Suna
dc.contributor.authorAkbulut, Kazime Gonca
dc.date.accessioned2025-02-24T17:18:58Z
dc.date.available2025-02-24T17:18:58Z
dc.date.issued2019
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Fizyoterapi ve Rehabilitasyon Bölümü
dc.description.abstractWe aimed to investigate the effect of melatonin and curcumin treatment on oxidative stress, apoptosis, and histology of testicular tissue in our study. Four groups were formed using young (4 months old, n = 6) and aged (20-22 months old, n = 18) male Wistar albino rats: (a) Young control (1% ethanol:phosphate-buffered saline [PBS], subcutaneously [s.c.]); (b) Aged control (CTL; n = 6, 1% ethanol:PBS, s.c.); (c) Aged Melatonin (MLT; n = 6, 10 mg/kg, s.c.); (d) Aged Curcumin (CUR; n = 6, 30 mg/kg, i.p.). At the end of 21 days, the rats were sacrificed, and testicular tissues were removed. Malondialdehyde (MDA) in the testicular tissue was determined with thiobarbituric acid reactive substances formation, and glutathione (GSH) was determined with modified Ellman method; testosterone level was determined with chemiluminescence method and histologic changes were determined with Haematoxylin-Eosin and Johnsen's scoring; Apoptotic cell counts were made with TUNEL staining of seminiferous tubule in testis. With ageing, MDA level increased in testicular tissue, but GSH and blood testosterone levels decreased. Melatonin treatment for aged rats significantly decreased Paired total testicular/body weight ratio compared to aged control group (p < 0.05). Curcumin treatment for aged rats significantly increased GSH level compared to the aged control group (p < 0.05). Besides, melatonin and curcumin treatment significantly decreased the number of apoptotic cells and significantly increased Johnsen's score (p < 0.05).
dc.identifier.doi10.1111/and.13203
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue3
dc.identifier.pmid30467869
dc.identifier.scopus2-s2.0-85056826284
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/and.13203
dc.identifier.urihttps://hdl.handle.net/20.500.14440/944
dc.identifier.volume51
dc.identifier.wosWOS:000460181300009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAndrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250201
dc.subjectageing
dc.subjectapoptosis
dc.subjectcurcumin
dc.subjectmelatonin
dc.subjectoxidative stress
dc.subjecttestis
dc.titleThe protective role of melatonin and curcumin in the testis of young and aged rats
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Sağlık Bilimleri Fakültesi Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu