Kübra Öztürk , Turan Emre Kuzu, Cem A Gürgan , Gözde Özge Önder , Arzu Yay

Makale/Derleme | 2023 | Lasers Med Sci 38 ( 1 ) , pp.169 - 169

The inferior alveolar nerve can be damaged during dental procedures, leading to symptoms, such as tingling, numbness, and reduced quality of life. Recovery depends on factors such as medications, surgery, and photobiomodulation therapy. Photobiomodulation therapy has shown the potential to improve nerve function and reduce regeneration time; however, there is no standard treatment protocol yet. This study aimed to examine the effect of diode lasers on nerve regeneration in patients with axonetmesis injuries. In this experiment on animals, Wistar rats' damaged sensory systems were treated with lasers to restore them. Animals were ran . . .domly divided into six groups: a sham group, a control group, and four laser treatment groups(1st group: performed every day, 10 sessions; 2nd group: performed every 2 days, 10 sessions; 3rd group: performed every day, 20 sessions; and 4th group: performed every 2 days, 20 sessions). Sensory function was determined using the Semmes-Weinstein monofilament test, which was repeated after the surgical procedure. The results showed that the 20-session group had the best improvement, most closely resembling the group without sensory test damage. The histomorphometric results showed that the number of axons was significantly lower in the group that received 10 daily sessions and in the control group than in the undamaged nerve. Axon diameter was lower in all groups than in the sham group. In conclusion, the remarkable aspect of this study is that consecutive-day 20-session laser treatment showed better improvement than the over-the-day 20-session treatment protocol Daha fazlası Daha az

Kuzu TE, Öztürk K, Gürgan CA

Makale/Derleme | 2023 | J Periodontal Res 58 ( 5 ) , pp.932 - 938

Objective: Paeoniflorin (Pae) is a monoterpene glycoside with immune-regulatory effects. Several studies have already demonstrated the impact of Pae on periodontitis, but its effect on diabetic periodontitis is unclear. In this study, our aim was to test the hypothesis that Pae had a strong anti-inflammatory effect that prevented bone loss in diabetic periodontitis. Methods: Thirty male Wistar albino rats were randomly divided into control (healthy, n = 10), periodontitis (PD) + diabetes (DM; n = 10), and PD + DM + Pae (n = 10) groups. Ligature-induced periodontitis was created by placing 4-0 silk ligatures around the lower first mo . . .lars on both sides of the mandibulae. Experimental DM was created via an injection of 50 mg/kg and streptozotocin (STZ). Hyperglycemia was confirmed by the blood glucose levels of rats (>300 mg/dL). The bone mineral density (BMD), trabecular number, trabecular thickness, and bone loss were measured by micro-CT. The expression levels of IL-1β, IL-6, and TNF-α were measured in tissue homogenates by ELISA. Results: The PD + DM + Pae group had significantly less alveolar crest resorption when compared to the PD + DM group. There was also a significant difference between the PD + DM + Pae group compared to PD + DM group in trabecular thickness, BMD, and the number of trabeculae. Pae application led to a statistically significant decrease in IL-1β, IL-6, and TNF-α levels in diabetic periodontitis. Conclusion: Systemic application of Pae suppressed inflammation caused by PD and DM, leading to reduced bone loss and enhanced bone quality Daha fazlası Daha az

Kübra Öztürk , Turan Emre Kuzu , Semih Ayrıkçil , Cem Abdulkadir Gürgan ,

Makale/Derleme | 2023 | Int J Implant Dent 9 ( 1 ) , pp.50 - 50

Purpose: Hypocholesterolemic medications similar to atorvastatin are efficient in lowering blood lipid levels; however, compared to other medications in the statin family, their impact on bone metabolism is claimed to be insufficient. The impact of atorvastatin on bone regeneration in dental implantology in individuals with hyperlipidemia who received atorvastatin in the clinic is doubtful. Methods: In the study, 16 male New Zealand rabbits of 6 months were used. All rabbits were fed a high-cholesterol diet for 8 weeks, and hyperlipidemia was created. It was confirmed that the total cholesterol level in rabbits was above 105 mg/dl. . . .A critical-sized defect was created in the mandible. The defect was closed with xenograft and membrane. Oral 10 mg/kg atorvastatin was started in the experimental group, and no drug was administered in the control group. At 16th week, animals were sacrificed. For histomorphological examination, the new bone area, osteoclast, and osteoblast activities were evaluated. Results: While new bone area (45,924 µm2, p < 0.001) and AP intensities (105.645 ± 16.727, p = 0.006) were higher in the atorvastatin group than in the control group, TRAP intensities in the control group (82.192 ± 5.346, p = 0.021) were higher than that in the atorvastatin group. Conclusions: It has been found that high blood lipid levels will adversely affect bone graft healing and the use of systemic atorvastatin contributes to bone healing. Clinicians should pay attention to the selection of surgical materials, considering the importance of questioning drug use in their patients and the risks in cases of non-use Daha fazlası Daha az

Merve ÇETİNKAYA SÖNMEZ

Makale/Derleme | 2023 | Adıyaman Üniversitesi Sosyal Bilimler Enstitüsü Dergisi ( 45 ) , pp.183 - 217

Kadim Anadolu Türk kültüründe doğa yerleşim dokularının biçimlenmesinde belirleyici olurken yapı bünyelerinde yer alan açık yeşil alan varlığı da daima tasarım bileşeni olarak değerlendirilmiştir. Doğa ve onun mekânsal yansıması olan açık yeşil alan tasarımları Anadolu yapı, kent kültüründe önemini korumuş alternatif kullanımlar sunacak biçimde ve farklı ölçeklerde açık mekân kurgulamaları gerçekleştirilmiştir. Anadolu yerleşmeler tarihi irdelendiğinde tüm uygarlıklarda görülen açık mekân biçimlenmeleri bir süreklilik izleyerek özgün Anadolu sentezi doğrultusunda farklı ölçek, kimlik ve nitelikte biçimlenmeler ile AnadoluTürk açık m . . .ekân kültürünü oluşturmuştur. Bu kapsamda gerek toplumsal gerek bireysel kullanımlara yönelik geleneksel açık mekanlar ve yeşil alanlar kent bütününde/kent dokusunda biçim bulmuştur. Avlular, bahçeler, korular, çayırlar, mesireler, bostanlar, dutluklar, meyvelikler bu kültürün ürünü ve belli işlevler içinde tasarlanan alanlar olarak Anadolu Türk kenti açık yeşil alan varlığını oluşturmuştur. Bu araştırmada Anadolu Türk kültüründe insan-doğa ilişkisinin belli kullanımlar doğrultusunda yorumlanması sonucunda gelişen geleneksel yeşil alanlar kavramsal olarak tanımlanmış, mekânsal, yapısal ve bitkisel anlamda gerek literatür verileri gerekse bugüne ulaşan alanlar kapsamında irdelenmiştir. Türk kültüründe görülen geleneksel açık mekân biçimlenmeleri mekânsal, işlevsel, ekolojik, sosyal, kültürel ve görsel nitelikleri ile ortaya konmuş; oluşumu ve tasarımındaki düşünsel arka plan irdelenmiştir. Yanı sıra Anadolu uygarlıklarının sentezi olan özgün açık yeşil alan tasarımı, çözümlerinin güncel tasarımlarda değerlendirilme olanakları tartışılmıştır Daha fazlası Daha az