Eda BAŞMISIRLI

Bildiri | 2021 | Espen 2021 , pp.242 - 242

Rationale: Hypertension is a serious medical condition and can increase the risk of heart, brain, kidney and other diseases. Accordingt to the World Heart Organisation (WHO): It is a major cause of premature death worldwide, with upwards of 1 in 4 men and 1 in 5 women (over a billion people) having the condition This study, which was planned as a randomized controlled intervention study, was conducted to compare the effects of the Dietary Approaches to Stop Hypertension (DASH) and salt-free diet on blood pressure in patients with hypertension.

Eda BAŞMISIRLI

Bildiri | 2021 | Espen 2021 , pp.750 - 750

Rationale: This intervention study, which was planned as a prospective randomized controlled, was conducted to compare the effects of perioperative nutritional support with immunonutrition and standard enteral products on postoperative complications and quality of life in patients with head and neck cancer (HNC). Methods: Between April February 2019 and February 2021, the study was conducted in Erciyes University Faculty of Medicine and Kayseri City Hospital Otolaryngology and Head Neck Surgery Clinic with 34 hospitalized patients with a diagnosis of HNC. Five days before surgery and 10 days postoperatively, immunonutrition suppor . . .t was given to the intervention group (n¼17), and standard enteral nutrition support was given to the control group (n¼17). Five days before surgery, 10th and 40th postoperative days; body analyzes were made, food consumption records were taken, Nutritional Risk Score (NRS) -2002 and quality of life scales (EORTC QLQ-C30, EORTC QLQ-H & N35) were applied, biochemical parameters, complications, length of hospital stay and nutritional support has been recorded. Results: Although there was no difference in energy intake between the intervention and control groups on the preoperative and 10th postoperative day, protein intake was significantly higher in the intervention group on the 10th postoperative day (p0.05). The NRS-2002 scores of the intervention and control groups increased on the 10th postoperative day (2.65±1.37, 3.18±1.13, respectively) compared to the preoperative period (2.0±1.28, 2.65±1.37, respectively), and decreased again on the 40th day (2.06±1.30, 2.71±1.31, respectively, p>0.05). Serum albumin levels decreased on the 10th postoperative day compared to the preoperative period, both in the intervention group (3.86±0.51 mg/dL) and in the control group (3.60±0.41 mg/dL, p0.05). Conclusion: In conclusion, compared to the perioperative standard enteral nutritional support, immunonutrition support provides an improvement in some components of quality of life scales. However, it has been shown that studies with longer follow-up and larger samples are required to observe its effect on complications. Disclosure of Interest: None declare Daha fazlası Daha az

Yusuf AYKEMAT

Makale/Derleme | 2021 | Nothern Clinics Of Istanbul

Objective: Klebsiella pneumoniae, a Gram-negative pathogen, especially which produces carbapenemase, is seen as a major threat to public health due to rapid plasmid-mediated spread of resistance and limited therapeutic options available for treatment. Although colistin has been recognized as a last resort antimicrobial for multidrug-resistant K. pneumoniae infections, these isolates have developed resistance to colistin as a result of its intensive use. The aim of this study was to evaluate the efficacy of double-carbapenem treatment of colistin-resistant K. pneumoniae experimental sepsis in mice.Methods: In the study, 8-10-week-old . . . Balb-c mice were divided as control groups (positive and negative) and treatment groups (colistin, ertapenemmeropenem, and ertapenemmeropenemcolistin). Sepsis was developed in mice by an intraperitoneal injection of colistin resistant K. pneumoniae. Antibiotics were given intraperitoneally 3 h after bacterial inoculation. Mice in each subgroup were sacrificed with overdose anesthetic at the end of 24-48 h and cultures were made from the heart, lung, liver, and spleen. Furthermore, homogenates of lung and liver were used to detect the number of colony-forming units per gram. Bacterial clearance was evaluated in lung and liver at different time points.Results: When the quantitative bacterial loads in the lung and liver tissues are evaluated, no statistically significant difference was observed between different antibiotic treatments (p>0.05). All three treatment options were not effective, especially in 24 h. Only the decrease in bacterial load at the 48th h of the group treated with ertapenem meropenem colistin was found significant ( Daha fazlası Daha az