Effect of systemic atorvastatin on bone regeneration in critical-sized defects in hyperlipidemia: an experimental study

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dc.authoridOnder, Gozde Ozge/0000-0002-0515-9286
dc.authoridYay, Arzu Hanim/0000-0002-0541-8372
dc.authoridAyrikcil, Semih/0000-0002-1606-4151
dc.authoridGURGAN, CEM/0000-0003-0811-008X
dc.contributor.authorOzturk, Kuebra
dc.contributor.authorKuzu, Turan Emre
dc.contributor.authorAyrikcil, Semih
dc.contributor.authorGurgan, Cem Abdulkadir
dc.contributor.authorOnder, Gozde Ozge
dc.contributor.authorYay, Arzu
dc.date.accessioned2025-02-24T17:18:40Z
dc.date.available2025-02-24T17:18:40Z
dc.date.issued2023
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.description.abstractPurpose Hypocholesterolemic medications similar to atorvastatin are efficient in lowering blood lipid levels; however, compared to other medications in the statin family, their impact on bone metabolism is claimed to be insufficient. The impact of atorvastatin on bone regeneration in dental implantology in individuals with hyperlipidemia who received atorvastatin in the clinic is doubtful.Methods In the study, 16 male New Zealand rabbits of 6 months were used. All rabbits were fed a high-cholesterol diet for 8 weeks, and hyperlipidemia was created. It was confirmed that the total cholesterol level in rabbits was above 105 mg/dl. A critical-sized defect was created in the mandible. The defect was closed with xenograft and membrane. Oral 10 mg/kg atorvastatin was started in the experimental group, and no drug was administered in the control group. At 16th week, animals were sacrificed. For histomorphological examination, the new bone area, osteoclast, and osteoblast activities were evaluated.Results While new bone area (45,924 mu m(2), p < 0.001) and AP intensities (105.645 +/- 16.727, p = 0.006) were higher in the atorvastatin group than in the control group, TRAP intensities in the control group (82.192 +/- 5.346, p = 0.021) were higher than that in the atorvastatin group.Conclusions It has been found that high blood lipid levels will adversely affect bone graft healing and the use of systemic atorvastatin contributes to bone healing. Clinicians should pay attention to the selection of surgical materials, considering the importance of questioning drug use in their patients and the risks in cases of non-use.
dc.description.sponsorshipNuh Naci Yazgan University Scientific Research Projects Coordination Unit [2019-SA.DH-BP/1]
dc.description.sponsorshipThis study was supported by the Nuh Naci Yazgan University Scientific Research Projects Coordination Unit (2019-SA.DH-BP/1).
dc.identifier.doi10.1186/s40729-023-00508-9
dc.identifier.issn2198-4034
dc.identifier.issue1
dc.identifier.pmid38097856
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/s40729-023-00508-9
dc.identifier.urihttps://hdl.handle.net/20.500.14440/773
dc.identifier.volume9
dc.identifier.wosWOS:001125924200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Japan Kk
dc.relation.ispartofInternational Journal of Implant Dentistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250201
dc.subjectHyperlipidemia
dc.subjectXenograft
dc.subjectAtorvastatin
dc.subjectBone regeneration
dc.titleEffect of systemic atorvastatin on bone regeneration in critical-sized defects in hyperlipidemia: an experimental study
dc.typeArticle

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