Polı?kı?stı?k over sendromlu infertı?l hastalarda koenzim Q10 kullanımının tüp bebek tedavisi sonucuna etkisinin araştırılması
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Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Nuh Naci Yazgan Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Retrospektif olarak planlanan bu araştırma; Kayseri''de özel bir kadın ve doğum hastanesinde yaşları 27,3±3,9 yıl olan polikistik over sendromlu infertil 154 kadında Koenzim Q10 (IVF) sonuçlarına etkisinin araştırılması amacıyla yürütülmüştür. Bu çalışmanın verileri 2019-2021 tarihleri arasında Kayseri'de bulunan özel bir Kadın Hastalıkları ve Doğum Hastanesinde IVF tedavisi almış olan PKOS'lu hasta dosyalarından, elde edilmiştir. Hastalar IVF tedavisi öncesi bir ay süre ile 100 mg Koenzim Q10 kullananlar (n= 75) ve kullanmayanlar (n=79) olmak üzere iki grupta incelenmiştir. Hastaların BKI, oosit kaliteleri, HbA1c düzeyleri, gebelik oluşumu ve canlı doğum gibi reprodüktif bulguları kaydedilmiş ve elde edilen veriler Mann Whitney U, Kikare ve Fisher Exact testleri ile analiz edilmiştir. Koenzim Q 10 kullananlarda M2 oosit sayısı (p<0,001) ve fertilizasyon (2 PN) oranları (p<0,05), gebelik oluşumu (p=0,001), klinik gebelik (p=0,001) ve canlı doğum (p=0,001) gerçekleşme oranları, kullanmayanlardan yüksek bulunmuştur. PKOS'lu infertil şişman Koenzim Q10 kullanan hastaların klinik gebelik (p=0,015) ve canlı doğum (p=0.046) oranları arasında Koenzim Q10 kullanmayan hastalara göre istatistiksel olarak yüksek bulunmuştur. Çalışma sonucunda her iki gruba da IVF uygulanmış olması nedeniyle Koenzim Q10 kullananlarda gebelik oluşumu ve canlı doğum oranlarının kullanmayanlardan yüksek olması nedeniyle Koenzim Q10 takviyesinin IVF sonuçlarını olumlu yönde etkilediği belirlenmiş, ancak, bu konuda daha uzun süreli ve daha fazla örneklem sayısı ile yapılmış çalışmalara gerek olduğu düşünülmüştür.
This study was planned retrospectively and it was conducted to investigate the effect of Coenzyme Q10 use on in vitro fertilization results in 154 infertile women with polycystic ovary syndrome, aged 27.3±3.9 years, in a private women's and maternity hospital in Kayseri. The data of this study were obtained from the files of patients with Polycystic Ovary Syndrome (PCOS) who received In Vitro Fertilization (IVF) treatment in a private Gynecology and Obstetrics Hospital in Kayseri between 2019 and 2021. The patients were examined in two groups, those who used 100 mg CoQ10 for one month before IVF treatment (n= 75) and those who did not (n=79). Reproductive findings of the patients such as oocyte quality, pregnancy formation and live birth were recorded and HbA1c levels, and, the obtained data were analyzed with Mann Whitney U, Chi-square and Fisher Exact tests. M2 oocytes count (p<0.001) and fertilization (2 PN) rates (p<0.05), pregnancy occurrence (p=0.001), clinical pregnancy (p=0.001) and live birth (p=0.001) in coenzyme Q 10 users realization rates were higher than those who did not use it. The clinical pregnancy (p=0.015) and live birth (p=0.046) rates of infertile fat patients with PCOS using CoQ10 were found to be statistically higher than the patients who did not use CoQ10. As a result of the study, it was determined that CoQ10 supplementation had a positive effect on IVF results since that IVF was applied to both groups, pregnancy formation and live birth rates were higher in those who used CoQ10 than in those who did not have been considered.
This study was planned retrospectively and it was conducted to investigate the effect of Coenzyme Q10 use on in vitro fertilization results in 154 infertile women with polycystic ovary syndrome, aged 27.3±3.9 years, in a private women's and maternity hospital in Kayseri. The data of this study were obtained from the files of patients with Polycystic Ovary Syndrome (PCOS) who received In Vitro Fertilization (IVF) treatment in a private Gynecology and Obstetrics Hospital in Kayseri between 2019 and 2021. The patients were examined in two groups, those who used 100 mg CoQ10 for one month before IVF treatment (n= 75) and those who did not (n=79). Reproductive findings of the patients such as oocyte quality, pregnancy formation and live birth were recorded and HbA1c levels, and, the obtained data were analyzed with Mann Whitney U, Chi-square and Fisher Exact tests. M2 oocytes count (p<0.001) and fertilization (2 PN) rates (p<0.05), pregnancy occurrence (p=0.001), clinical pregnancy (p=0.001) and live birth (p=0.001) in coenzyme Q 10 users realization rates were higher than those who did not use it. The clinical pregnancy (p=0.015) and live birth (p=0.046) rates of infertile fat patients with PCOS using CoQ10 were found to be statistically higher than the patients who did not use CoQ10. As a result of the study, it was determined that CoQ10 supplementation had a positive effect on IVF results since that IVF was applied to both groups, pregnancy formation and live birth rates were higher in those who used CoQ10 than in those who did not have been considered.
Açıklama
Anahtar Kelimeler
Beslenme ve Diyetetik, Nutrition and Dietetics
