Correlation between the expressions of leptin and its receptors (ObR, sObR) in gastric cancer

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dc.authoridCAKIR, Isil/0000-0001-5728-4671
dc.authoridcakir, nuri/0000-0002-9935-7397
dc.contributor.authorCakir, Isil
dc.contributor.authorKilic, Eser
dc.contributor.authorCoskun, Banu Demet Ozel
dc.contributor.authorCakir, Nuri
dc.contributor.authorSavaşçıhabeş, Asuman
dc.date.accessioned2025-02-24T17:19:11Z
dc.date.available2025-02-24T17:19:11Z
dc.date.issued2016
dc.departmentFakülteler, Mühendislik Fakültesi, Elektrik-Elektronik Mühendisliği Bölümü
dc.description.abstractObjective: The expressions of leptin and its receptor (ObR) have been observed in human gastric cancer (GC) tissue. Leptin can promote the proliferation of GC cells. However, the correlation between leptin and ObR expressions in GC and the role of gastric ObR protein levels in patients with GC is still unclear. This study aimed to evaluate the relationship between leptin, gastric ObR protein and soluble leptin receptor (sObR) levels and whether their possible role of indicator in GC. Methods: Serum leptin, gastric leptin and serum sObR concentrations were determined in 30 male patients with GC and 25 male dyspeptic subjects by enzyme linked immunosorbent assay. We analysed the expression of gastric ObR levels in endoscopically obtained biopsy samples by using Western Blotting method. Results: Compared with controls, patients had lower serum leptin and higher gastric tissue leptin levels. sObR protein concentrations of patients were detected significantly higher, gastric ObR protein expression were lower than subjects in control group. Conclusion: Leptin in gastric cancerous region and sObR in circulation are overexpressed in GC. Their expressions are associated with malignancy. Decreased leptin levels, induces the sObR signal in circulation. This negative feedback regulation is also seen in gastric tissue: increased gastric tissue leptin levels inhibits gastric ObR protein expression. Thus, leptin and ObR may be important indicators in GC.
dc.description.sponsorshipErciyes University Scientific Research Projects Unit
dc.description.sponsorshipThe authors thank the Endoscopy Unit of Gastroenterology Department and for financial support, they thank to Erciyes University Scientific Research Projects Unit.
dc.identifier.doi10.1515/tjb-2016-0035
dc.identifier.endpage249
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue4
dc.identifier.scopus2-s2.0-84982840390
dc.identifier.scopusqualityQ3
dc.identifier.startpage243
dc.identifier.trdizinid224906
dc.identifier.urihttps://doi.org/10.1515/tjb-2016-0035
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/224906
dc.identifier.urihttps://hdl.handle.net/20.500.14440/1041
dc.identifier.volume41
dc.identifier.wosWOS:000387205500002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250201
dc.subjectGastric cancer
dc.subjectLeptin
dc.subjectObR
dc.subjectsObR
dc.subjectWestern blot
dc.titleCorrelation between the expressions of leptin and its receptors (ObR, sObR) in gastric cancer
dc.typeArticle

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