Antimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate

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dc.contributor.authorBoran Gülen, Rukiye
dc.contributor.authorBaygar, Tuba
dc.contributor.authorSaraç, Nurdan
dc.contributor.authorAyrıkçil, Semih
dc.contributor.authorYılmaz, Derviş
dc.contributor.authorUğur, Aysel
dc.date.accessioned2025-02-24T16:28:45Z
dc.date.available2025-02-24T16:28:45Z
dc.date.issued2023
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Radyolojisi Ana Bilim Dalı
dc.description.abstractBoron containing compounds (BCGs) have recently been used for pharmaceutical applications. Zinc, an essential element, is known to be one of the most promising biodegradable metals. The present study was conducted to determine the wound healing properties of zinc borate with its antimicrobial, antifibrinolytic and enzyme inhibitory characteristics. In vitro scratch wound healing assay revealed that zinc borate at 0.01 µg/mL concentration stimulated the proliferation of 3T3 fibroblast cells after 24 h of scar formation. The highest enzyme inhibition was observed against collagenase at 1 mg/mL (81.5%). Minimum inhibition concentration (MIC) values were determined as 1 mg/mL and 0.5 mg/mL against Candida albicans and Staphylococcus aureus, respectively. Zinc borate did not have any fibrinolytic activity at 1, 0.5 and 0.1 mg/mL concentrations. It can be suggested that zinc borate can be used effectively to improve the wound healing process and to prevent the possible wound infections.
dc.identifier.doi10.30728/boron.1180847
dc.identifier.endpage104
dc.identifier.issn2149-9020
dc.identifier.issn2667-8438
dc.identifier.issue3
dc.identifier.startpage99
dc.identifier.trdizinid1199580
dc.identifier.urihttps://doi.org/10.30728/boron.1180847
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1199580
dc.identifier.urihttps://hdl.handle.net/20.500.14440/408
dc.identifier.volume8
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofBOR DERGİSİ
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20250201
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectDermatoloji
dc.subjectGenel ve Dahili Tıp
dc.subjectRehabilitasyon
dc.subjectMikrobiyoloji
dc.subjectSağlık Bilimleri ve Hizmetleri
dc.subjectTıbbi Laboratuar Teknolojisi
dc.subjectCerrahi
dc.titleAntimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate
dc.typeArticle

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