THE EFFECT OF CAROB (CERATONIA SILIQUA L.) AGAINST NICOTINE BASED OXIDATIVE STRESS

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dc.contributor.authorNisari, Mustafa
dc.contributor.authorYılmaz, Seher
dc.contributor.authorGöçmen, Ayşe Yeşim
dc.contributor.authorÖztekin, Ünal
dc.contributor.authorAteş, Şükrü
dc.contributor.authorŞeker Karatoprak, Gökçe
dc.contributor.authorİnanç, Neriman
dc.date.accessioned2025-02-24T16:28:51Z
dc.date.available2025-02-24T16:28:51Z
dc.date.issued2024
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractOBJECTIVE: In this study the antioxidant effect of carob plant, ıt's effects of nicotine-induced oxidative stress and the number of pyramidal cells in the rat hippocampus in cornu ammonis (CA) were investigated. MATERIAL AND METHODS: In the study, 28 adult Wistar Albino male rats were used. Rats are divided into four groups as control group, carob group, nicotine group and nicotine + carob group. Nicotine was applied to the experimental group, and carob extract was applied to the treatment group as well as nicotine. Superoxide dismutase (SOD), glutathione (GSH), glutathione disulfide (GSSG), total oxidant capacity (TOS), total antioxidant capacity (TAS) values were measured by spectrophotometric analysis on the lung, brain, kidney, heart and liver tissues. Oxidative stress index (OSI) and GSH / GSSG values, respectively, were calculated as TOS/TAS and GSH/GSSG rates. The number of pyramidal cells in the CA was estimated using the optical fractionator technique. RESULTS: It is seen that the TAS level in the kidney tissue of the nicotine group is significantly lower than the control and carob groups. In brain tissue, the TAS level of the nicotine group was significantly lower than that of other groups (p<0.001). The OSI value of the nicotine group was significantly higher in liver tissue compared to the control group (p<0.001). Nicotine exposure has been shown to cause a significant reduction in the number of pyramidal cells in CA. CONCLUSIONS: It is understood that Carob plant is an important phytomedical plant that has antioxidant properties against nicotine by increasing TAS level in oxidative stress formation.
dc.identifier.doi10.18229/kocatepetip.1133332
dc.identifier.endpage15
dc.identifier.issn1302-4612
dc.identifier.issn3061-9904
dc.identifier.issue1
dc.identifier.startpage8
dc.identifier.trdizinid1221730
dc.identifier.urihttps://doi.org/10.18229/kocatepetip.1133332
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1221730
dc.identifier.urihttps://hdl.handle.net/20.500.14440/443
dc.identifier.volume25
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofKocatepe Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20250201
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectNörolojik Bilimler
dc.subjectFizyoloji
dc.subjectBiyokimya ve Moleküler Biyoloji
dc.subjectPsikiyatri
dc.titleTHE EFFECT OF CAROB (CERATONIA SILIQUA L.) AGAINST NICOTINE BASED OXIDATIVE STRESS
dc.typeArticle

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