May argyrophilic nucleolar organizing region-associated protein synthesis be used for selecting the most reliable dose of drugs such as rhamnetin in cancer treatments?

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dc.authoridNisari, Mustafa/0000-0001-7469-8921
dc.authoridBIRCAN KADIOGLU, DUYGU/0000-0002-5956-9774
dc.authoridErtekin, Tolga/0000-0003-1756-4366
dc.contributor.authorErtekin, T.
dc.contributor.authorBozkurt, O.
dc.contributor.authorEroz, R.
dc.contributor.authorNisari, M.
dc.contributor.authorBircan, D.
dc.contributor.authorNisari, M.
dc.contributor.authorUnur, E.
dc.date.accessioned2025-02-24T17:18:47Z
dc.date.available2025-02-24T17:18:47Z
dc.date.issued2016
dc.departmentNuh Naci Yazgan
dc.description.abstractBACKGROUND: Rhamnetin is a flavonoid that has antioxidant, anti-inflammatory and anti-cancer effects. Nucleolar-organizing regions are the ribosomal genes region. We aimed to identify whether rhamnetin has an effect on cell proliferation and whether AgNOR proteins may be used for the detection of therapeutic benefits of the drugs and new metabolites, which have the potential of being used for cancer treatments. METHODS: Twenty-four mice with Ehrlich's ascites carcinoma (EAC) were randomly assigned to three main groups as positive control, and groups 2 and 3 treated intraperitoneally with rhamnetin (100 mu g/kg and 200 mu g/kg, respectively). All the animals were sacrificed on day 16, 24 h after the last dose; the tumors, which developed at the site of injection were removed. Then, mean AgNOR number and total AgNOR area/nuclear area (TAA/NA) were detected for each mouse. RESULTS: Significant differences were detected among all groups for mean AgNOR number (p = 0.000) and TAA/NA ratio (p = 0.000). While the difference between positive control and Rhamnetin (100 mu g/kg) group was not significant (p = 0.387), there are signifi cant differences between positive control and Rhamnetin (200 mu g/kg) group (p = 0.000) and between Rhamnetin (100 mu g/kg) and Rhamnetin (200 mu g/kg) groups (p = 0.000) for TAA/NA ratio. CONCLUSION: Rhamnetin has an important role in preventing cancer formation. Our study showed that mean AgNOR numbers and TAA/NA values may be used also as biomarkers for evaluating the success rate of the performed therapeutic strategy and accurate dose selection for the management of the disease (Tab. 3, Fig. 3, Ref. 45). Text in PDF www.elis.sk.
dc.description.sponsorshipErciyes University [EU-BAP- THD-2016-6499]
dc.description.sponsorshipThis work was supported by Erciyes University (EU-BAP- THD-2016-6499).
dc.identifier.doi10.4149/BLL_2016_126
dc.identifier.endpage658
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue11
dc.identifier.pmid28125891
dc.identifier.scopus2-s2.0-85014946437
dc.identifier.scopusqualityQ2
dc.identifier.startpage653
dc.identifier.urihttps://doi.org/10.4149/BLL_2016_126
dc.identifier.urihttps://hdl.handle.net/20.500.14440/857
dc.identifier.volume117
dc.identifier.wosWOS:000388707600006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univ
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250201
dc.subjectNOR
dc.subjectAgNORs
dc.subjectrhamnetin
dc.subjectcancer treatments
dc.subjectrDNA
dc.titleMay argyrophilic nucleolar organizing region-associated protein synthesis be used for selecting the most reliable dose of drugs such as rhamnetin in cancer treatments?
dc.typeArticle

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