Does childhood chemotherapy affect mandibular bone structures in a lifetime?

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dc.authoridkis, hatice cansu/0000-0003-4956-7537
dc.authoridDelikan, Ebru/0000-0003-1624-3392
dc.authoridCosgunarslan, Aykagan/0000-0002-4988-4500
dc.authoridAksu, Seckin/0000-0002-5196-215X
dc.contributor.authorKis, Hatice Cansu
dc.contributor.authorCosgunarslan, Aykagan
dc.contributor.authorDelikan, Ebru
dc.contributor.authorAksu, Seckin
dc.date.accessioned2025-02-24T17:18:30Z
dc.date.available2025-02-24T17:18:30Z
dc.date.issued2022
dc.departmentNuh Naci Yazgan
dc.description.abstractBackground. Chemotherapy, one of the most important treatment modalities for treating childhood cancers, is a major cause of bone loss in patients and survivors.Objectives.This study aimed to evaluate mandibular bone structures in childhood cancer survivors (CCSs) by means of fractal dimension (FD) analysis and the Klemetti index (KI), and to compare them with regard to the control group.Material and methods. In this retrospective study, the panoramic radiographs of 49 CCSs were included as the study group and the panoramic radiographs of 49 cancer-free volunteers were included as the control group. Based on the panoramic radiographs, FD and KI were determined.Results. No significant differences were observed between the study and control groups in terms of mean FD values for regions of interest (ROIs) ROI_1, ROI_2 and ROI_3 (p = 0.750, p = 0.490 and p = 0.910, respectively). The mean FD values for ROI_1 for the study and control groups were 1.08 +/- 0.18 and 1.07 +/- 0.14, respectively. The mean FD values for ROI_2 for the study and control groups were 1.11 +/- 0.13 and 1.09 +/- 0.13, respectively. The mean FD values for ROI_3 for the study and control groups were 1.15 +/- 0.14 and 1.15 +/- 0.15, respectively. Statistically significant differences between the study and control groups were noted only in the distribution of the KI categories (p = 0.015).Conclusions. Childhood chemotherapy may affect mandibular bone structures during a lifetime. The Klemetti index should be considered a useful clinical diagnostic tool for the examination of mandibular bone structures.
dc.identifier.doi10.17219/dmp/146752
dc.identifier.endpage501
dc.identifier.issn1644-387X
dc.identifier.issn2300-9020
dc.identifier.issue4
dc.identifier.pmid36459049
dc.identifier.scopus2-s2.0-85145026187
dc.identifier.scopusqualityQ2
dc.identifier.startpage495
dc.identifier.urihttps://doi.org/10.17219/dmp/146752
dc.identifier.urihttps://hdl.handle.net/20.500.14440/707
dc.identifier.volume59
dc.identifier.wosWOS:000892645900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWroclaw Medical Univ
dc.relation.ispartofDental and Medical Problems
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250201
dc.subjectpediatric oncology
dc.subjectpanoramic radiography
dc.subjectfractals
dc.subjectchildhood chemotherapy
dc.titleDoes childhood chemotherapy affect mandibular bone structures in a lifetime?
dc.typeArticle

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