Rhamnetin improves antioxidant status in the liver of Ehrlich solid tumor bearing mice

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dc.authorid0000-0001-5026-4133
dc.authorid0000-0001-7469-8921
dc.contributor.authorİnanç, Neriman
dc.contributor.authorNisari, Mustafa
dc.contributor.authorGüneş, Ömer
dc.contributor.authorSoylu, Meltem
dc.contributor.authorTascılar, Emre
dc.contributor.authorSerdar, Muhittin A.
dc.date.accessioned2025-04-16T21:39:35Z
dc.date.available2025-04-16T21:39:35Z
dc.date.issued2020
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractObjective:Rhamnetin, a flavanol, is in the subclasses of the flavonoids existing in plants. The antioxidant properties of several plants containing flavonoids have been extensively studied in several diseases including cancer. This study investigated the effects of rhamnetin on tumor masses, oxidant and antioxidant status in the livers of mice bearing Ehrlich solid tumor. Material and Methods:Fifty male Balb/C mice weighing 25-30 g were used in the study. Ten mice were keptfor Ehrlich ascites tumor (EAT) cells production and the remaining mice were randomly assigned to four groups containing 10 mice in each as healthy control and treatments receiving 1x106 EAT cells and EAT cells plus 100 ?g/kg/day or 200 ?g/kg/day rhamnetin via subcutaneous route. The tumor inhibition rates of rhamnetin treatments were calculated. The livers were analyzed for malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) levels. Results:Compare to tumor control, both levels of rhamnetin suppressed tumor masses throughout the experiment. The MDA levels were increased whereas SOD and CAT activities were reduced by EAT cells injection in the liver of mice. The 100 ?g/kg/day rhamnetin treatment decreased MDA level but 200 ?g/kg/day rhamnetin had no significant effect on increased MDA level. The reduced liver SOD (p<0.001) and CAT (p<0.01) activities were elevated by both levels of rhamnetin injection. Conclusions:The results of this study have revealed that rhamnetin suppresses tumor progression and improves antioxidant status in the livers of solid tumor-bearing mice
dc.identifier.doi10.36472/msd.v7i5.380
dc.identifier.endpage500
dc.identifier.startpage494
dc.identifier.urihttps://doi.org/10.36472/msd.v7i5.380
dc.identifier.urihttps://hdl.handle.net/20.500.14440/1087
dc.identifier.volume7
dc.identifier.wosN/A
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorİnanç, Neriman
dc.institutionauthorNisari, Mustafa
dc.language.isoen
dc.publisherMedical Science and Discovery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Kurum_20250417
dc.subjectEhrlich solid tumor
dc.subjectLipid peroxidation
dc.subjectAntioxidant enzymes
dc.subjectRhamnetin
dc.titleRhamnetin improves antioxidant status in the liver of Ehrlich solid tumor bearing mice
dc.typeArticle

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