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    Effect of Curcumin on Testis in Mice with Ehrlich Ascites Tumor
    (Fazile Nur Ekinci Akdemir, 2020) Yilmaz, Seher; Göçmen, Yeşim; Tokpınar, Adem; Ateş, Şükrü; Nisari, Mustafa; Caniklioğlu, Aysen; Öztekin, Ünal
    In the current work, the effects of curcumin on testicular tissues in Ehrlich Ascites Tumor (EAT) model developed in Balb/C mice. EAT cells (1x106) received from stock of animals were injected intraperitoneally to animals. 25mg/kg and 50mg/kg of curcumin was administered intraperitoneally. Testicular tissues obtained after all the experiment were evaluated for histopathological and biochemical parameters. Histopathological results showed that 50 mg/kg curcumin group had less EAT cells around testicular tissues than tumor control group. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities and reduced glutathione (GSH), oxide glutathione (GSSG), total antioxidant status (TAS), total oxidant status (TOS), interleukin-1beta (IL-1?), interleukin-6, interleukin-17, tumor necrosis factor-alfa (TNF-?) levels were measured in testis tissues. Oxidative stress index (OSI) and GSH/GSSG ratio were calculated. Findings clearly suggested that antioxidant parameters (except CAT and GPx) had higher value in animal models treated with 25 and 50 mg curcumin groups associated to tumor control group. There was a statistically noteworthy variance between the groups in all parameters. Antitumor effect of curcumin on ascites tumor cells produced by EAT cells evidenced with histopathological while antioxidant and anti-inflammatory biochemical parameters evidenced with biochemical parameters.
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    Effects of Fenugreek Extract on Total Antioxidant/Oxidant Status at Ehrlich Ascites Tumor Bearing Mice
    (2020) Nisari, Mustafa; Alpa, Serife; Yilmaz, Seher; Inanç, Neriman
    Objectives: In this study, we aimed to effect of extract that derived from fenugreek on total antioxidant/oxidant statusat Ehrlich ascites tumor bearing Balb/C mice.Methods: The phenolic of Fenugreek extract was calculated as gallic acid equivalent using Folin-Ciocalteu method.Fenugreek extract concentration determined 200–400 mg/kg. In the end of in vivo studies, while the weight of experimental animals was estimated.Results: It was found that fenugreek extract delaying the weight gain. Administered fenugreek extract group hadlower serum TOS and OSI index and had higher serum TAS compared to the control group. These effects were higher inthe group receiving fenugreek 400 mg/kg intraperitoneally.Conclusion: As a result, the fenugreek extract shows antioxidant effect on EAT cells. We believe that our studies will beguiding for new studies about fenugreek and fenugreek could be advised as a food because of its antioxidant effect.Thus, it may have anticancer effect.