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    Assessment of Thyroid Function Tests in Patients with COVID-19 Infection and Their Relationship with Euthyroid Sick Syndrome
    (2022) Aslaner, Hümeyra; Benli, Ali Ramazan; Çetin, Adil; Erten, Zeliha Kaya; Mıstık, Selçuk; Şimşek, Yasin
    Aim: Thyroid functions are affected by many factors functions such as some infections and drugs. This study aimed to investigate how the thyroid function tests were affected after COVID-19 infection and their relationship with euthyroid sick syndrome.Material and Method: Our study was designed as a retrospective and case-control study. The participants consisted of two groups as the control and patient groups. Thyroid function tests (TFT), hemogram and routine biochemistry of the groups were assessed. In addition, the tests of the patient group within the last 6 months before the infection were assessed. The patients’ symptoms, presence of a chronic disease, smoking history, and clinical status during COVID-19 infection were recorded.Results: A total of 473 people were included in the study. Of the participants, 54.5% were female. The white blood count (WBC), hemoglobin (HGB), platelet (PLT), and neutrophil (NEU) counts were higher in the patient group. Lymphocyte (LY) and mean platelet volume (MPV) counts were similar. Tyroid stimulating hormone (TSH) and triiodothyronine (T3) values of the patients were higher compared with the control group. The thyroxine (T4) level was similar in the two groups.TSH, T3 and T4 levels of the patient group before COVID-19 were higher than the results just after the quarantine process after COVID-19 infection.Conclusion: Thyroid dysfunction develops in COVID-19 patients within the course of the disease. This condition can be partially explained with the euthyroid sick syndrome. It is also possible with the thyroid gland being the direct or indirect target of the virus. 
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    COVID-19 Relapse and Reinfection Frequency, Clinical Features of Cases
    (2022) Aslaner, Hümeyra; Aslaner, Hacı Ahmet; Savranlar, Yasemin; Benli, Ali Ramazan
    Purpose: How the immune response of people infected with SARS-CoV-2 develops against the virus and how long its effectiveness is one of the most important questions during the pandemic period. We aimed to examine the frequency of relapse and re-infection, examine the influencing factors, evaluate the cases' clinical conditions and symptoms, and examine the severity of subsequent infection. Materials and Methods: This is a descriptive and cross-sectional type study using the Public Health Management System (PHMS) records of the Turkish Ministry of Health. Clinical improvement and negative RT-PCR test results, and positive RT-PCR test results at least 45 days after the first infection were included in this study. The cases were divided into two groups: the relapse group, those positive for 45-89 days after the first infection, and the reinfection group after 90 days recommended by the CDC. Demographic characteristics, whether or not to be a health worker, accompanying chronic illness, and re-positivity periods were evaluated. Results: The total number of cases was 103.096. The number of cases with repeat positivity detected after 45 days was 78. In the study, the number of cases in the relapse group (45-89 days) was 49, while the number of cases in the reinfection group (over 90 days) was 29. Conclusions: The very low rate of reinfection and milder symptoms in the second infection are promising for vaccination studies. Understanding the COVID-19 reinfection could be the key to guiding government and public health decisions in the coming months.
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    Prevalence of COVID-19 infection in asymptomatic school children
    (Turkish J Pediatrics, 2022) Aslaner, Humeyra; Benli, Ali Ramazan; Simsek, Erhan; Korkmaz, Zubeyde
    Background. With the onset of the COVID-19 pandemic, discussions regarding the prevalence of COVID-19 in children and the association of this with education have started. This study aimed to determine the prevalence of COVID-19 infection in asymptomatic school children within a limited period while face-to-face education continued. Methods. This is a descriptive and retrospective study. Screening was carried out in the schools in the three major districts of the metropolitan municipality when face-to-face education was practiced. COVID-19 RT-PCR swab samples were collected from 4,658 students from 46 schools at preschool, primary, secondary, and high school levels by using the stratified sampling method. Screening results were retrospectively analyzed by the researchers. Results. The mean age of the children included in the study was 10.6 +/- 3.2 (5-17). Only 46 students' COVID-19 RT-PCR results were positive; the positivity rate was higher in male students than in female students (p>0.05); the students living in the third region had a higher positivity rate than the other students, there was a statistical difference between them (p<0.001); there were no positive cases in 26 (56.7%) schools, and the spreader rate of the school children was 0.98%. Conclusions. We determined in the study that the prevalence of COVID-19 infection was not high in asymptomatic school children in the period when schools were open. This may play a role in directing the education and training during the pandemic.
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    The Effect of Vitamin B12 Levels on Prognosis in COVID-19 Patients
    (Rabia YILMAZ, 2022) Aslaner, Hümeyra; İnanç, Neriman; Gökçek, Mebrure Beyza; Aykemat, Yusuf; Aslaner, Hacı Ahmet; Benli, Ali Ramazan
    Objectives: It is known that vitamins have some effects such as suppressing viral replication, developing anti-inflammatory responses and that they increase immunity in COVID-19. This study aimed to investigate the correlation between the vitamin B12 (Vit B12) serum levels and the prognosis of the disease in patients with COVID-19. Material and Method: A total of 408 participants were included in the study. Sociodemographic information such as age, educational status, serum vitamin B12 levels, hemogram parameters, and clinical findings of the patients who were admitted for follow-up after the end of COVID-19 infection was evaluated retrospectively. Serum vitamin B12 level between 150-200 pg/mL was assessed as mild deficiency, the value between 100-150 pg/mL as severe deficiency and the value under 100 pg/mL as extremely severe deficiency. Results: Median age of the participants was 44.51 (18-88) years. The median Vit B12 level of the patients was 179.50 (75-641). Of the patients, 248 (60.70%) had Vit B12 deficiency. The rates of pneumonia and hospitalization were higher and fatigue and loss of taste/smell were more in patients with Vit B12 deficiency. NLR and PLR which are the inflammatory markers were higher in patients with Vit B12 deficiency. The rates of pneumonia and hospitalization were the highest in the severe Vit B12 deficiency group among the Vit B12 deficiency groups. Conclusion: The clinical progression was worse in COVID-19 patients with Vit B12 deficiency than those who had no Vit B12 deficiency. Therefore, it has been concluded that Vitamin B12 supplement can have positive effects on COVID-19 patients; however, more comprehensive further studies with longer duration and higher number of patients are needed.