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    Assessment of Thyroid Function Tests in Patients with COVID-19 Infection and Their Relationship with Euthyroid Sick Syndrome
    (2022) Aslaner, Hümeyra; Benli, Ali Ramazan; Çetin, Adil; Erten, Zeliha Kaya; Mıstık, Selçuk; Şimşek, Yasin
    Aim: Thyroid functions are affected by many factors functions such as some infections and drugs. This study aimed to investigate how the thyroid function tests were affected after COVID-19 infection and their relationship with euthyroid sick syndrome.Material and Method: Our study was designed as a retrospective and case-control study. The participants consisted of two groups as the control and patient groups. Thyroid function tests (TFT), hemogram and routine biochemistry of the groups were assessed. In addition, the tests of the patient group within the last 6 months before the infection were assessed. The patients’ symptoms, presence of a chronic disease, smoking history, and clinical status during COVID-19 infection were recorded.Results: A total of 473 people were included in the study. Of the participants, 54.5% were female. The white blood count (WBC), hemoglobin (HGB), platelet (PLT), and neutrophil (NEU) counts were higher in the patient group. Lymphocyte (LY) and mean platelet volume (MPV) counts were similar. Tyroid stimulating hormone (TSH) and triiodothyronine (T3) values of the patients were higher compared with the control group. The thyroxine (T4) level was similar in the two groups.TSH, T3 and T4 levels of the patient group before COVID-19 were higher than the results just after the quarantine process after COVID-19 infection.Conclusion: Thyroid dysfunction develops in COVID-19 patients within the course of the disease. This condition can be partially explained with the euthyroid sick syndrome. It is also possible with the thyroid gland being the direct or indirect target of the virus. 
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    COVID-19 Relapse and Reinfection Frequency, Clinical Features of Cases
    (2022) Aslaner, Hümeyra; Aslaner, Hacı Ahmet; Savranlar, Yasemin; Benli, Ali Ramazan
    Purpose: How the immune response of people infected with SARS-CoV-2 develops against the virus and how long its effectiveness is one of the most important questions during the pandemic period. We aimed to examine the frequency of relapse and re-infection, examine the influencing factors, evaluate the cases' clinical conditions and symptoms, and examine the severity of subsequent infection. Materials and Methods: This is a descriptive and cross-sectional type study using the Public Health Management System (PHMS) records of the Turkish Ministry of Health. Clinical improvement and negative RT-PCR test results, and positive RT-PCR test results at least 45 days after the first infection were included in this study. The cases were divided into two groups: the relapse group, those positive for 45-89 days after the first infection, and the reinfection group after 90 days recommended by the CDC. Demographic characteristics, whether or not to be a health worker, accompanying chronic illness, and re-positivity periods were evaluated. Results: The total number of cases was 103.096. The number of cases with repeat positivity detected after 45 days was 78. In the study, the number of cases in the relapse group (45-89 days) was 49, while the number of cases in the reinfection group (over 90 days) was 29. Conclusions: The very low rate of reinfection and milder symptoms in the second infection are promising for vaccination studies. Understanding the COVID-19 reinfection could be the key to guiding government and public health decisions in the coming months.
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    Post-discharge evaluation of patients treated in hospital with infection of Covid-19
    (2021) Kaya Erten, Zeliha; Çetin, Adil; Gökçek, Mebrure Beyza; Özçakır, Ayşenur Canan; Aslaner, Hümeyra
    Objective: This study was conducted retrospectively, cross-sectional and descriptively, with the aim of evaluating the results of monitoring that carried out by telephone, of discharged patients who had been hospitalised due to Covid-19 during the pandemic. Method: The population of the research contains of folders of 862 patients who got their Covid-19 Polymerase Chain Reaction (PCR) tests positive, treated in hospital and discharged between 28.08.2020 and 16.09.2020. Study was completed with folders complete datawise of 760 patients. Descriptive statistics were given in mean, standard deviation, median, minimum and maximum. Percentages were used for categorical data. Also, in order to determine intergroup differences in categorical variables, Chi-Square test was used. Kolmogorov-Smirnov test was used for analysing normal distribution of data.Results: In the study, age median of patients that stated their clinical condition good and medium was lower than the patients of poor clinical condition (p:0.001). 45 of patients with poor condition were rehospitalized and 35 of them applied to emergency service (p<0.001) Conclusion: Results demonstrate that patients have continued problems in their homes and need support after discharge. Moreover, it was reasoned that home-monitoring and home attendant care services for elderly patients have to be improved qualitatively. Key Words: Covid-19, Follow-up at home, Discharge,
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    Post-discharge evaluation of patients with Covid-19 infection
    (2022) Çetin, Adil; Gökçek, Mebrure Beyza; Aslaner, Hümeyra; Erten, Zeliha Kaya; Benli Özçakır, Ayşenur Canan
    Introduction: This study was conducted retrospectively, cross-sectional and descriptively to evaluate the telemonitoring results of discharged patients who had been hospitalized due to Covid-19 during the pandemic.Methods: This study was composed of data which were obtained through the folders of 862 patients who had gotten their Covid-19 Polymerase Chain Reaction (PCR) tests positive, were treated in hospital and discharged between 28.08.2020 and 16.09.2020. This study was completed with folders of 760 patients whose data were overall. Descriptive statistics were given as mean, standard deviation, median, minimum and maximum. Percentages were used for categorical data. Also, the Chi-Square test was used to determine differences between the groupsin categorical variables. Kolmogorov-Smirnov test was used so as to analyze normal distribution of data.Results: In the study, the age median of patients who stated their clinical condition as good and average, was lower compared to patients whose clinical status was bad (p=0.001). 45% of patients with poor condition were rehospitalized and 35% of them were directed to emergency service (p<0.001).Conclusions: Results have demonstrated that even if those patients were discharged, their problems still continued in their homes, and they need support. Moreover, it is considered that home-monitoring and home attendant care services for elderly patients have to be improved qualitatively.
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    The Effect of Vitamin B12 Levels on Prognosis in COVID-19 Patients
    (Rabia YILMAZ, 2022) Aslaner, Hümeyra; İnanç, Neriman; Gökçek, Mebrure Beyza; Aykemat, Yusuf; Aslaner, Hacı Ahmet; Benli, Ali Ramazan
    Objectives: It is known that vitamins have some effects such as suppressing viral replication, developing anti-inflammatory responses and that they increase immunity in COVID-19. This study aimed to investigate the correlation between the vitamin B12 (Vit B12) serum levels and the prognosis of the disease in patients with COVID-19. Material and Method: A total of 408 participants were included in the study. Sociodemographic information such as age, educational status, serum vitamin B12 levels, hemogram parameters, and clinical findings of the patients who were admitted for follow-up after the end of COVID-19 infection was evaluated retrospectively. Serum vitamin B12 level between 150-200 pg/mL was assessed as mild deficiency, the value between 100-150 pg/mL as severe deficiency and the value under 100 pg/mL as extremely severe deficiency. Results: Median age of the participants was 44.51 (18-88) years. The median Vit B12 level of the patients was 179.50 (75-641). Of the patients, 248 (60.70%) had Vit B12 deficiency. The rates of pneumonia and hospitalization were higher and fatigue and loss of taste/smell were more in patients with Vit B12 deficiency. NLR and PLR which are the inflammatory markers were higher in patients with Vit B12 deficiency. The rates of pneumonia and hospitalization were the highest in the severe Vit B12 deficiency group among the Vit B12 deficiency groups. Conclusion: The clinical progression was worse in COVID-19 patients with Vit B12 deficiency than those who had no Vit B12 deficiency. Therefore, it has been concluded that Vitamin B12 supplement can have positive effects on COVID-19 patients; however, more comprehensive further studies with longer duration and higher number of patients are needed.