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Bulunan: 26 Adet 0.002 sn
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Filtreler
Bulunan: 26 Adet 0.002 sn
BM Sürdürülebilir Kalkınma [1]
Tam Metin [1]
Alt Tür [1]
Alt Tür 1 [2]
Bilimsel Araştırma Etkinlikleri [1]
Açık Erişim Tarihi [2]
Dizin Platformu [4]
Doç. Dr. Mustafa NİSARİBeslenme ve Diyetetik
Erişime Açık

Investigation of argyrophilic nucleolar organizing region

Mustafa Nisari

BACKGROUND: Ischemia/reperfusion (I/R) injury is a complex event frequently observed in vascular surgery and can cause functional and structural cell damage. Nucleolar-organizing regions (NORs) are sites of the ribosomal genes located on chromosomes and can be stained with silver when they are active. Thus these proteins are named as argyrophilic-NOR (AgNOR)-associated proteins. We aimed to investigate any possible effects of renal I/R injury on the NOR protein synthesis and association between the AgNOR proteins amount and histopathological injuring score. METHODS: Nine female wistar-albino r ...Daha fazlası

Erişime Açık

İskemi/reperfüzyon hasarı oluşturulan ratlarda melatoninin böbrek fonksiyonları üzerine etkisi

Mustafa NİSARİ | Neriman İNANÇ | Eda BAŞMISIRLI

Amaç: Serbest oksijen radikalleri iskemi/reperfüzyon(I/R) esnasında patofizyolojik doku değişimlerine neden olmaktadır. Bu çalışmada deneysel iskemi/reperfüzyonun sıçan böbreklerinde yol açtığı oksidatifhasara karşı güçlü bir antioksidan olan melatonininböbrek fonksiyonları ve böbrek hasarı üzerindeki etkilerinin araştırılması amaçlandı.Gereç ve Yöntem: Çalışmada 200-250 g ağırlığında 28adet dişi Wistar albino rat kullanıldı. Ratlar rastgele 4gruba ayrıldı (n=7). Kontrol grubu (K): Hayvanlara herhangi bir ilaç enjeksiyonu ya da I/R işlemi yapılmadı. I/R grubu: Herhangi bir ilaç enjeksiyonu yap ...Daha fazlası

Erişime Açık

Rhamnetin improves antioxidant status in the liver of Ehrlich solid tumor bearing mice

Neriman İNANÇ | Mustafa NİSARİ

Objective:Rhamnetin, a flavanol, is in the subclasses of the flavonoids existing in plants. The antioxidant properties of several plants containing flavonoids have been extensively studied in several diseases including cancer. This study investigated the effects of rhamnetin on tumor masses, oxidant and antioxidant status in the livers of mice bearing Ehrlich solid tumor. Material and Methods:Fifty male Balb/C mice weighing 25-30 g were used in the study. Ten mice were keptfor Ehrlich ascites tumor (EAT) cells production and the remaining mice were randomly assigned to four groups containing 1 ...Daha fazlası

Erişime Açık

Effects of fenugreek extract on total antioxidant/oxidant status at ehrlich ascites tumor bearing mice, ejmı

Neriman İNANÇ | Mustafa NİSARİ

Cancer is the second most common cause of death in the world. Several natural products have been studied for anticancer activity and for the prevention or repair of oxidative injury. Curcumin is one of the natural products of high medicinal interest. This study was performed to investigate the effects of curcumin on lipid peroxidation and antioxidant enzymes in tissues of mice bearing Ehrlich solid tumor. Forty mice were distributed to four groups as healthy control and treatments that received 1x106 Ehrlich ascites tumor (EAT) cells and EAT cells plus 25 mg/kg/day or 50 mg/kg/day curcumin wit ...Daha fazlası

Erişime Açık

Investigation of dose related effects of propolis on anxiety and some biochemical parameters with sympathetic skin response and increased T-maze

Mustafa Nisari

Aim: Propolis has been shown to have anti-microbial, antioxidant, anti-tumor, anxiolytic and anti-inflammatory effects. However, to the best of our knowledge, there are no studies on its anxiogenic effects. In this study, we aimed to investigate the effects of different doses of propolis on anxiety in rats with cold stress via sympathetic skin response (electrodermal activity) and elevated T maze. Methods: Forty Wistar albino male rats were used in the study, divided into four groups: The control group, low dose (10 mg/kg PRO), medium dose (30 mg/kg PRO) and high dose propolis groups (50 mg/kg ...Daha fazlası

Erişime Açık

Uric acid-lymphocyte ratios and myocardial damage parameters in ST elevated myocardial infarction

Mustafa NİSARİ

Aim: Major negative cardiovascular outcomes and uric acid (UA), neutrophil: lymphocyte ratio (NLR) and lymphocyte levels have been demonstrated in up-to-date studies. In this study, it was aimed to investigate ULAR in patients with STEMI and unstable angina pectoris (UAP) who underwent primary percutaneous coronary intervention. For this purpose, we evaluated relationships between UALR and markers of myocardial injury (troponin I, creatine kinaseMB) inflammatory markers (high-sensitivity C-reactive protein [hsCRP]) and blood count parameters), serum lipids and myocardial contractility. Materia ...Daha fazlası

Erişime Açık

Effects of MTHFR C677T gene polymorphism on migraine together with biochemical and clinical parameters in Turkish population

Mustafa NİSARİ

o detect the relation between methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and both of clinical and biochemical parameters. One hundred sixty migraine patients and one hundred twenty control group were included in the current study. Pain intensity of individuals were measured, biochemical, clinical parameters and MTHFR C677T single nucleotide polymorphism were detected. Statistically higher occurrence MTHFR C677T genotype was detected in migraine group than control group. A statistically significant association between family history of migraine and MTHFR C677T genotypes ...Daha fazlası

Erişime Açık

Biochemical effects of caffeine and melatonin on rat embryo brain

Mustafa NİSARİ

Background:Oxidative stress plays an important role in fetus brain development. The aim of this study was to investigate the protective role of melatonin against the effect of caffeine (given 30 mg/kg and 60 mg/kg) in embryo brain.Material and Methods:For this purpose, 35 adult female Sprague-Dawley rats were used in the study. Pregnant rats were detected by vaginal smear test and were divided into seven groups with five rats per group.Thirty(30) mg/kg and 60 mg/kg caffeine were administered to the experimental groups between the 1st and 20th days of pregnancy, while melatonin (10 mg/kg) was a ...Daha fazlası

Erişime Açık

Does capsaicin have therapeutic benefits in human colon adenocarcinoma? Selection of the most reliable dose via AgNOR

Mustafa Nisari

Background/aim To determine the effect of different doses of capsaicin on AgNOR protein synthesis in human colon adenocarcinoma derivate from colon cancer (Caco-2 cell). Materials and methods In this experimental study, after the cultured of Caco-2 cell line, the cells are divided into 4 groups as control and different capsaicin exposed doses (25uµ, 50uµ, and 75uµ). Mean AgNOR number and total AgNOR area/nuclear area (TAA/NA) were calculated. Results A significant differences were detected between control and capsaicin (50uµ) (P = 0.001), between control and capsaicin (75uµ) (P = 0.000), betwe ...Daha fazlası

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