Effect of systemic atorvastatin on bone regeneration in critical-sized defects in hyperlipidemia: an experimental study

Kübra Öztürk , Turan Emre Kuzu , Semih Ayrıkçil , Cem Abdulkadir Gürgan ,

Purpose: Hypocholesterolemic medications similar to atorvastatin are efficient in lowering blood lipid levels; however, compared to other medications in the statin family, their impact on bone metabolism is claimed to be insufficient. The impact of atorvastatin on bone regeneration in dental implantology in individuals with hyperlipidemia who received atorvastatin in the clinic is doubtful. Methods: In the study, 16 male New Zealand rabbits of 6 months were used. All rabbits were fed a high-cholesterol diet for 8 weeks, and hyperlipidemia was created. It was confirmed that the total cholestero ...Daha fazlası