Investigation of argyrophilic nucleolar organizing region

Mustafa Nisari

BACKGROUND: Ischemia/reperfusion (I/R) injury is a complex event frequently observed in vascular surgery and can cause functional and structural cell damage. Nucleolar-organizing regions (NORs) are sites of the ribosomal genes located on chromosomes and can be stained with silver when they are active. Thus these proteins are named as argyrophilic-NOR (AgNOR)-associated proteins. We aimed to investigate any possible effects of renal I/R injury on the NOR protein synthesis and association between the AgNOR proteins amount and histopathological injuring score. METHODS: Nine female wistar-albino r ...Daha fazlası

Makale/Derleme 2016 Bratisl Med J 2 Görüntülenme

Does capsaicin have therapeutic benefits in human colon adenocarcinoma? Selection of the most reliable dose via AgNOR

Mustafa Nisari

Background/aim To determine the effect of different doses of capsaicin on AgNOR protein synthesis in human colon adenocarcinoma derivate from colon cancer (Caco-2 cell). Materials and methods In this experimental study, after the cultured of Caco-2 cell line, the cells are divided into 4 groups as control and different capsaicin exposed doses (25uµ, 50uµ, and 75uµ). Mean AgNOR number and total AgNOR area/nuclear area (TAA/NA) were calculated. Results A significant differences were detected between control and capsaicin (50uµ) (P = 0.001), between control and capsaicin (75uµ) (P = 0.000), betwe ...Daha fazlası

Makale/Derleme 2020 Turkish Journal of Medical Sciences 9 Görüntülenme

May argyrophilic nucleolar organizing region-associated protein synthesis be used for selecting the most reliable dose of drugs such as rhamnetin in cancer treatments?

Mustafa NİSARİ

BACKGROUND: Rhamnetin is a fl avonoid that has antioxidant, anti-infl ammatory and anti-cancer effects. Nucleolar-organizing regions are the ribosomal genes region. We aimed to identify whether rhamnetin has an effect on cell proliferation and whether AgNOR proteins may be used for the detection of therapeutic benefi ts of the drugs and new metabolites, which have the potential of being used for cancer treatments. METHODS: Twenty-four mice with Ehrlich’s ascites carcinoma (EAC) were randomly assigned to three main groups as positive control, and groups 2 and 3 treated intraperitoneally with rh ...Daha fazlası

Makale/Derleme 2016 BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY 16 Görüntülenme

Detaylı Arama

Filtreler

Koleksiyon [3]

İlgili Araştırmacılar [1]

Tam Metin [1]

Tür [1]

Yazar [2]

Konu Başlıkları [10]

Açık Erişim Tarihi [1]

Tarih [2]

Dizin Platformu [1]

İsmi Geçen [2]

WOS Kategorileri [1]

Investigation of argyrophilic nucleolar organizing region

Mustafa Nisari

Does capsaicin have therapeutic benefits in human colon adenocarcinoma? Selection of the most reliable dose via AgNOR

Mustafa Nisari

May argyrophilic nucleolar organizing region-associated protein synthesis be used for selecting the most reliable dose of drugs such as rhamnetin in cancer treatments?

Mustafa NİSARİ