Biochemical effects of caffeine and melatonin on rat embryo brain

Mustafa NİSARİ

Background:Oxidative stress plays an important role in fetus brain development. The aim of this study was to investigate the protective role of melatonin against the effect of caffeine (given 30 mg/kg and 60 mg/kg) in embryo brain.Material and Methods:For this purpose, 35 adult female Sprague-Dawley rats were used in the study. Pregnant rats were detected by vaginal smear test and were divided into seven groups with five rats per group.Thirty(30) mg/kg and 60 mg/kg caffeine were administered to the experimental groups between the 1st and 20th days of pregnancy, while melatonin (10 mg/kg) was a ...Daha fazlası