Investigation of argyrophilic nucleolar organizing region

Mustafa Nisari

BACKGROUND: Ischemia/reperfusion (I/R) injury is a complex event frequently observed in vascular surgery and can cause functional and structural cell damage. Nucleolar-organizing regions (NORs) are sites of the ribosomal genes located on chromosomes and can be stained with silver when they are active. Thus these proteins are named as argyrophilic-NOR (AgNOR)-associated proteins. We aimed to investigate any possible effects of renal I/R injury on the NOR protein synthesis and association between the AgNOR proteins amount and histopathological injuring score. METHODS: Nine female wistar-albino r ...Daha fazlası

Makale/Derleme 2016 Bratisl Med J 2 Görüntülenme

May argyrophilic nucleolar organizing region-associated protein synthesis be used for selecting the most reliable dose of drugs such as rhamnetin in cancer treatments?

Mustafa NİSARİ

BACKGROUND: Rhamnetin is a fl avonoid that has antioxidant, anti-infl ammatory and anti-cancer effects. Nucleolar-organizing regions are the ribosomal genes region. We aimed to identify whether rhamnetin has an effect on cell proliferation and whether AgNOR proteins may be used for the detection of therapeutic benefi ts of the drugs and new metabolites, which have the potential of being used for cancer treatments. METHODS: Twenty-four mice with Ehrlich’s ascites carcinoma (EAC) were randomly assigned to three main groups as positive control, and groups 2 and 3 treated intraperitoneally with rh ...Daha fazlası

Makale/Derleme 2016 BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY 16 Görüntülenme